Noise reduction issue - ISO was lowish at 200 so I think the grain is more likely artefacts resulting from sharpening.
One workaround is to use selective sharpening : brush a mask over only the area that you want to sharpen and sharpen only the contents of the mask. I don't know how to do it in LR but relatively easy in CNX2 and PS. If shooting in RAW, consider disabling all in-camera sharpening and only apply sharpening selectively in postprocessing. It makes a big difference to grain/noise in the out-of-focus areas and may even allow you to get away without applying noise reduction and the associated loss of detail that results.
If necessary, you can then invert the same mask and apply noise reduction to the remaining area if required.
When applying the mask, I like to use a brush with some feathering (softening of the edges of the selected area) otherwise the interface between areas that were sharpened and those that were not can become visible.