I turn on the automatic sensor shaker option, such that it activates when I turn on and turn off the camera.
I have done this since day 1 on my D300 and D700. I have never had to wet clean the sensors and only very rarely get dust bad enough that I need to use a blower bulb on the exposed sensor.
The process is invisible to me and does not appear to slow down the turn on/off operation. I have over 70K images on both bodies and regularly change lenses in dusty environments. I've never found any downside to the automatic sensor shaker option.
I suspect that the constant sensor shaker "cleaning" gets the dust off the sensor before it can "stick", as dust tends to do.
I also regularly blow out the mirror box with my Giottos rocket bulb, along with the back end of the lens, just to get all the accumulated dust out. I usually don't lift the mirror unless I need to. In any event I keep the tip of the blower well outside the mirror box so that it can't get entangled in the mirror or shutter, which a Very Bad Thing.