I got my D800E as an upgrade from a D300 and the CA has been the biggest surprise. Were all of you meticulously using the Lens Correction profiles for the last three years. I wasn't. But now with D800E 36 MP files without a lens specific profile in Lightroom 4 the CA at 100% is BAD. That's what is to be expected when there's this many pixels in such a small space. I posted samples of my D800E trials to my blog and Flickr schafphoto photostream. Still trying to figure out the new workflow. But if you aren't using the lens profiles in your RAW converter then you might try that, it could improve your perceived sharpness.
Stephen Schafer Architectural/HABS/HAER/HALS Photography www.habsphoto.com. Ventura, California