I use to bring a heavy bag with multiple lenses but now I just travel with a lowepro passport sling.Big enougth to hold my d700 with my 24-120, an extra battery and cards. I bring a tripod if I plane to take some pictures inside or for some HDR shot.
In case I need to bring extra goods for my children I use a traditional backpack. Camera and lenses are carefuly protected and put on the top of the bag.
Computer and other stuff stay at home. Post processing is only made when I'm back.