I also have LaCie drives that I have on the desktop (http://www.lacie.com/us/products/product.htm?id=10476). I have used several sizes over the years, 500GB, 1TB, etc., and some have been in service for as long as 8 years. I use them in pairs so I have back that way as well. I usually work from the LaCie Drives and then back up to the off site RAID boxes.
I hope this might provide some help for your decision about HDs.