I tend to be a bit paranoid about my images, so when I ingest them into my computer from the CF card I save the NEF on 2 separate drives. One location is only for an archive of the original. The other is titled Nikon Transfer and sub folders are kept for each upload. I now use VNX2 to browse and rate the images in the Transfer folders. I work on my NEFs one at a time in CNX2. and when I am finished with my edit. I save the final image in a Processed folder sorted into general category folders and sub folders. Once I save that file using CNX2. I then use the CNX2 Open With command and open the NEF as a TIFF in Photoshop CS6 Extended. If I need to do any more editing, which is rare, I edit the TIFF and save a copy of the TIFF in the same folder as the processed NEF. In either case further processed or not I save a JPEG processed as Save for Web to a Nikonians upload folder for later posting. Weekly I do a backup of all images stored on my DATA drive which includes the original NEF, the Processed NEF and any Nikonian files to another Drive called Photos. That drive is also backed up weekly to a NAS drive as a second backup so that I have 3 complete copies of my photos plus the separate archive of the original NEF that I copied over. I never worry about losing an image this way.