I have been using DxO for many years and it is basically the only post processing program I use, though I have NX2 as well as PS. DxO integrates very well with LR4 which I mainly use for cataloging and searching. Just make sure that the appropriate DxO lens/camera modules are available. You may also want to download the user manual from the DxO site in order to gain a better understanding of the program's capabilities.
In case you are interested, there is a recent thread in the digital post processing forum which may answer some of your questions.