On a case by case D7000 discussion, many recommendations can be made.

Similar to an automobile, a question about a thumping noise coming from the left front would lead us to recommend that the OP check to see if the tire is flat.

But, also similar to an automobile, try to diagnose a P0300 computer code of random misfires on a 1997 Chevy S10, virtually impossible without standardizing the entire vehicle.

That is the basis for my request of a standardized test.

Oh, by the way, the next thing I am going to try on the S10 is to replace the worn distributor shaft alignment bushing, the truck has 248,000 miles.